MOTS-c
MOTS-c
A mitochondrial-derived peptide encoded within the *mitochondrial 12S rRNA gene. Research shows that it represents signaling from mitochondria to the nucleus regarding cellular energy status, inhibiting the folate–AICAR cycle, causing the cell to behave as if energy is limited, which activates the AMPK pathway. AMPK activation is shown to improve fuel utilization and activates NRF2, which regulates gene expression related to metabolism and stress response. Studies show that it targets skeletal muscle, liver, and *adipose tissue with high specificity.
Researched Benefits: Supports metabolic flexibility, mitochondrial function, inflammation reduction, bone density, memory, performance, and longevity.
Key Terms:
- Mitochondrial 12S rRNA Gene: A core component that helps mitochondria produce the proteins required for ATP (energy) production.
- Adipose Tissue: The body’s fat storage tissue that also plays an active role in metabolic regulation.
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